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Although the efficacy of GHK-Cu has been recognized, there are certain limitations in its application, such as higher cost, thicker skin feel, and intolerance to high temperatures
39 Most studies used B12 i.m., with slightly varying dosing regimens, commonly 1000 g daily for 57 days, followed by weekly injections for another 34 weeks, and then monthly injections
Once absorbed, semaglutide has a half-life of approximately one week, providing sustained glycaemic control with once-daily dosing
The Cochrane Risk of Bias tool was used to assess the quality of studies
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